Stem Cell Treatment for Spinal Cord Injury

A combination of stem cells and extensive therapies giving the patient real chances of improvement

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CELLAAX is a clinical-stage biopharmaceutical company engaged in the discovery, research, development and commercialization of Regenerative Medicine.

Spinal Cord Injury

Are you considering Stem Cell Treatment for Spinal Cord Injury?

Spinal cord injury is a debilitating condition affecting the spinal cord that has limited curative treatment options, with most only focusing on alleviating the present symptoms and improving daily functionality. Stem Cell Treatment however offers hope, with studies showing stem cell therapy can slow or stop the progression of spinal cord injury.

Read on to see if Spinal Cord Injury Stem Cell Treatment might be right for you.

How does stem cell treatment for spinal cord injury work?

Mesenchymal stem cells (MSC) have shown great potential for the treatment of spinal cord injuries due to their differentiation potential, immunomodulatory properties, secretion of growth factors and cytokines, migration and integration capabilities.MSCs secrete a variety of growth factors and cytokines that can promote nerve growth, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF). 

Stem cells can also induce the expression of neurotrophic factors, which are proteins that promote the growth and survival of neurons. Through promotion of angiogenesis, MSCs promote the formation of new blood vessels, which can provide oxygen and nutrients to support nerve growth.

How Stem Cell Therapy Improves Spinal Cord Injuries

Stem cells are cells that are “pluripotent”, meaning they can differentiate into all other cells due to their self-renewing abilities. They can develop into ectodermal (ex. skin and some neurological structures), mesodermal (ex. bones, cartilage, and blood cells), or endodermal cells (ex. cells of internal body organs). Therefore, injecting stem cells should theoretically allow them to differentiate and “replace” the damages neurons due to cord injury (1). However, following extensive testing of stem cell treatment on SCI patients, it has proven to have additional benefits other than tissue replacement; including (7):

  • Replacing and repairing the damaged neurons: This is their original function; to replace the damaged tissue by conversion of one cell type to another.
  • Increasing the production of neurotrophic factors: That promote nervous cell proliferation and differentiation (ex. glia derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF))
  • Modulating the immune system and the ongoing inflammatory process – thereby reducing the ongoing neurodestructive process due to SCI
  • Promoting vascular supply to the nervous system through stimulating the generation of new blood vessels (neovascularization/angiogenesis)
  • Increasing survival of damaged neurons: Stem cells can prevent apoptosis/automated cell death; therefore promoting cell survival and improving recovery.
Patient Outcome Data - Spinal Cord Injury

The table below highlights the findings from a questionnaire completed by 76 patients who underwent stem cell treatment with Beike Cell Therapy for Spinal Cord Injury. This survey was tailored to capture insights regarding patient satisfaction, the perceived effectiveness of the stem cell treatment, and any potential areas that might require enhancement.

The collated responses have been meticulously organized to offer a comprehensive view of the patients’ experiences and the results of their treatment.

Data collated on 5 December 2024

% of Patients who noticed Improvement % of Patients who noticed a Small Improvement % of Patients who noticed a Moderate Improvement % of Patients who noticed a Large Improvement
Trunk muscle strength 73% 41% 19% 13%
Limb muscle strength 71% 41% 17% 13%
Upper limb muscle tone 75% 41% 22% 12%
Upper limb strength 71% 29% 26% 16%
Trunk sensation 64% 36% 17% 10%
Upper limb sensation 67% 33% 18% 16%
Lower limb muscle tone 55% 32% 17% 7%
Fine motor control 59% 43% 7% 9%
Skin condition 57% 19% 19% 20%
Fatigue 57% 30% 19% 8%
Sweating 60% 35% 12% 12%
Control of body temperature 61% 36% 16% 9%
Lower limb strength 50% 28% 15% 7%
Lower limb sensation 48% 31% 9% 8%
Pain 49% 25% 18% 6%
Bladder control 38% 22% 13% 3%
Bowel control 37% 21% 11% 4%
Sexual function 37% 28% 8% 2%
Do you feel as though your stem cell treatment has improved the quality of life?

 

No41%
Yes, has slightly improved41%
Yes, has moderately improved14%
Yes, has significantly improved4%
% of patients with some level of positive result59%

Are you currently satisfied with the outcome of the treatment?
No 20%
No Comment 13%
Somewhat satisfied 41%
Yes 26%
% of patients a positive level of satisfaction 67%
Are you currently experiencing any improvements in your general physical condition?
No26%
Yes, small improvements43%
Yes, moderate improvements23%
Yes, significant improvements7%
% of Patients with ongoing improvements74%

Benefits of Stem Cell Therapy in Spinal Cord Injury

The purpose of stem cell therapy is to promote the healing of the original injury in order to restore neurological function. Thus, various kinds of improvement are possible after our treatment. Our past patients have experienced the following among others*:

  • Improve motor strength and power
  • Improve sensation
  • Pain Reduction
  • Increase sweating function
  • Improve muscle tension
  • Improve self-care capacity
  • Decreased spasticity


*It is important to remember that as for any medical treatment, improvements cannot be guaranteed. Please contact us for more information regarding the possible improvements for a particular case.